HSP70-NUCLEOTIDE EXCHANGE FACTOR (NEF) FES1 HAS NON-NEF ROLES IN DEGRADATION OF GLUCONEOGENIC ENZYMES AND CELL WALL INTEGRITY.

Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity.

Fes1 is a conserved armadillo repeat-containing Hsp70 nucleotide exchange factor important for growth at high temperature, proteasomal protein degradation and prion propagation.Depleting or mutating Fes1 induces a stress response and causes defects in these processes that are ascribed solely to disruption of nipple-suckers Fes1 regulation of Hsp70.

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